Microgennet

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MICROGENNET the micronutrient genomics network

Microgennet is an EU funded exchange program that is closely related to the micronutrient genomics project ([MGP]).

The aim of MICROGENNET is the extension, enhancement and strengthening of established collaborations for the purpose of a community-driven knowledge base for micronutrient genomics.

MICROGENNET is a collaboration of 16 distinguished universities and research institutes worldwide. The overall aim of the exchange programme is to build, extend and strengthen sustainable collaborations between the partners so as to create a community driven knowledge base for micronutrient genomics research. Currently, the data on nutrient effects on health are scattered in publications and databases around the world. The aim of this work is to provide a public portal and bioinformatics toolbox to access and analyse collaborative and publicly available data. Ultimately the goal is to develop individualized intake recommendations for specific micronutrients to promote prevention of both acute illness and chronic disease.The exchange objective is provide researchers with: an international platform to learn novel techniques and methods, the opportunity to formulate new joint collaborative research and funding proposals and international exposure and intercultural understanding. The exchange programme consists of visits ranging from 1-7 months for ESRs and ERs. The expertise and facilities of the partners are highly complementary and the synergy lies in the combination of expertise on identifying metabolic and functional target pathways for a range of micronutrients (Selenium, Zinc, Vitamins and vitamin-related compounds anti-oxidants) and bioinformatics expertise on pathway analysis and data integration. The concise work plan consists of 4 work packages, 2 related to data collection concerning minerals and vitamins, a third over-arching bioinformatic workpackage and one for management. The consortium will be sustainable through its close association with the Micronutrient Genomics Project and the Europe-led NuGO association. MICROGENNET contributes to the EC priorities because it uses mobility to transfer knowledge and will create a network through which European centres of excellence will enhanced through links with researchers from the rest of the world.

Microgennet is funded by the EU Marie Curie action program IRSES grant 269210.

Mariecurie.jpeg

The Microgennet programme

Microgennet consists of four workpackages:

Microgennet partners

Procedures

Microgennet management documentation

Procedures to prepare and report exchanges

Ethical Issues

Overview Exchanges

Gantt chart


Dissemination


Microgennet meetings and conferences

  • Kick-off meeting

A kick-off meeting was held in Volendam, the Netherlands on September 19th, 2011 during yhe micronutrient genomics project (MGP) meeting.
Slides MICROGENNET kick-off meeting - Chris Evelo (project manager)

  • Project meeting

A Microgennet project meeting was held prior to the International Conference on Nutrigenomics (INCON) at San Jose, Costa Rica on October 1st, 2012. The complete program of the INCON (pre) meeting can be found here.
Agenda pre-meeting

  • Micronutrient genomics project (MGP) and MICROGENNET workshop on September 10th, 2015

A workshop held in connection with NuGOWeek 2015 (8,9 September 2015)
The preliminary Program
The location of the workshop can be found here.
To register and more information please check the workshops website


Lectures

  • NuGOweek 2012

During NuGOweek 2012 several MICROGENNET partners presented their work. This 9th NuGO week was entitled: Nutrition, lifestyle and genes in the changing environment and held on 28-31 August, 2012 in Helsinki, Finland. A detailed description of the program is available at link.

  • NuGOweek 2013

The MICROGENNET partners were also present at NuGOweek in 2013 and presented their work at this conference. The 10th NuGOweek on “Nutrigenomics and more” was held from 9-12 September 2013 in Freising (Munich), Germany. A detailed description of the program is available at http://www.nugo.org/nugoweek/42384/5/0/30.

  • NuGOweek 2014

During NuGOweek 2014 several MICROGENNET partners presented their work. This 11th NuGO week was entitled: Nutrigenomics and Foods and held on 8-11 September, 2014 in Naples, Italy.

  • NuGOweek 2015

The MICROGENNET partners were also present at NuGOweek in 2015 and presented their work at this conference. The 12th NuGOweek on “Mechanisms of a long-life health” was held from 7-9 September 2015 in Barcelona, Spain. A detailed description of the program is available at http://www.nugo.org/nugo-week/2010-2014/nugoweek-2015/programme/

At the conferences listed below MICROGENNET research was presented as keynotes.

  • International Conference of Nutrigenomics (INCON) - 2012

This conference was held in Costa Rica and was entitled: Gene and diet interaction for personalized health and disease prevention. MICROGENNET was introduced in a pre-conference meeting and several MICROGENNET partners presented their work. A detailed description of the program is available at http://www.micronutrientgenomics.org/images/a/ae/INCON-program.pdf

  • 12th European Nutrition Conference FENS 2015

MICROGENNET was represented by several partners at this conference in Berlin, Germany. A complete overview of the progam is available at: http://www.fensberlin2015.org/index.php?seccion=programme&subSeccion=programme

  • Keystone meeting on Human Nutrition, Environment and Health 2015.

During the first Keystone meeting related to human nutrition several MICROGENNET partners presented their research. For a program see https://www.keystonesymposia.org/index.cfm?e=Web.Meeting.Program&meetingid=1388&subTab=program

News

The Grant Agreement for Microgennet has now been fully signed and the project was officially launched.

October 26 2011: First Microgennet paper published

Publications

Ben van Ommen, Ahmed El-Sohemy, John Hesketh, Jim Kaput, Michael Fenech, Chris T Evelo, Harry J McArdle, Jildau Bouwman, Georg Lietz, John C Mathers, Sue Fairweather-Tait, Henk van Kranen, Ruan Elliott, Suzan Wopereis, Lynnette R Ferguson, Catherine Méplan, Giuditta Perozzi, Lindsay Allen, Damariz Rivero, Micronutrient Genomics Project Working Group
The Micronutrient Genomics Project: a community-driven knowledge base for micronutrient research.
Genes Nutr: 2010, 5(4);285-96
[PubMed:21189865] [WorldCat.org] [DOI] (I p)

Martina Kutmon, Susan L Coort, Kim de Nooijer, Claire Lemmens, Chris T Evelo
Integrative network-based analysis of mRNA and microRNA expression in 1,25-dihydroxyvitamin D3-treated cancer cells.
Genes Nutr: 2015, 10(5);484
[PubMed:26276506] [WorldCat.org] [DOI] (P p)

Jill A McKay, Michiel Adriaens, Chris T Evelo, Dianne Ford, John C Mathers
Gene promoter DNA methylation patterns have a limited role in orchestrating transcriptional changes in the fetal liver in response to maternal folate depletion during pregnancy.
Mol Nutr Food Res: 2016, 60(9);2031-42
[PubMed:27133805] [WorldCat.org] [DOI] (I p)

Matthew P G Barnett, Emma N Bermingham, Wayne Young, Shalome A Bassett, John E Hesketh, Anabel Maciel-Dominguez, Warren C McNabb, Nicole C Roy
Low folate and selenium in the mouse maternal diet alters liver gene expression patterns in the offspring after weaning.
Nutrients: 2015, 7(5);3370-86
[PubMed:26007332] [WorldCat.org] [DOI] (I e)

Catherine Méplan, Lars Ove Dragsted, Gitte Ravn-Haren, Anne Tjønneland, Ulla Vogel, John Hesketh
Association between polymorphisms in glutathione peroxidase and selenoprotein P genes, glutathione peroxidase activity, HRT use and breast cancer risk.
PLoS ONE: 2013, 8(9);e73316
[PubMed:24039907] [WorldCat.org] [DOI] (I e)

Emma N Bermingham, John E Hesketh, Bruce R Sinclair, John P Koolaard, Nicole C Roy
Selenium-enriched foods are more effective at increasing glutathione peroxidase (GPx) activity compared with selenomethionine: a meta-analysis.
Nutrients: 2014, 6(10);4002-31
[PubMed:25268836] [WorldCat.org] [DOI] (I e)

Nina Roswall, Signe B Larsen, Søren Friis, Malene Outzen, Anja Olsen, Jane Christensen, Lars O Dragsted, Anne Tjønneland
Micronutrient intake and risk of prostate cancer in a cohort of middle-aged, Danish men.
Cancer Causes Control: 2013, 24(6);1129-35
[PubMed:23519640] [WorldCat.org] [DOI] (I p)

Giulia Ranaldi, Simonetta Ferruzza, Raffaella Canali, Guido Leoni, Peter D Zalewski, Yula Sambuy, Giuditta Perozzi, Chiara Murgia
Intracellular zinc is required for intestinal cell survival signals triggered by the inflammatory cytokine TNFα.
J. Nutr. Biochem.: 2013, 24(6);967-76
[PubMed:22967671] [WorldCat.org] [DOI] (I p)

Nina Roswall, Anja Olsen, Jane Christensen, Louise Hansen, Lars O Dragsted, Kim Overvad, Anne Tjønneland
Micronutrient intake in relation to all-cause mortality in a prospective Danish cohort.
Food Nutr Res: 2012, 56();
[PubMed:22489215] [WorldCat.org] [DOI] (I p)

Chiara Murgia, Dion Grosser, Ai Q Truong-Tran, Eugene Roscioli, Agnes Michalczyk, Margaret Leigh Ackland, Meredin Stoltenberg, Gorm Danscher, Carol Lang, Darryl Knight, Giuditta Perozzi, Richard E Ruffin, Peter Zalewski
Apical localization of zinc transporter ZnT4 in human airway epithelial cells and its loss in a murine model of allergic airway inflammation.
Nutrients: 2011, 3(11);910-28
[PubMed:22254085] [WorldCat.org] [DOI] (I p)

Guido Leoni, Antonio Rosato, Giuditta Perozzi, Chiara Murgia
Zinc proteome interaction network as a model to identify nutrient-affected pathways in human pathologies.
Genes Nutr: 2014, 9(6);436
[PubMed:25367142] [WorldCat.org] [DOI] (P p)

Rhys Hamon, Claire C Homan, Hai B Tran, Violet R Mukaro, Susan E Lester, Eugene Roscioli, Mariea D Bosco, Chiara M Murgia, Margaret Leigh Ackland, Hubertus P Jersmann, Carol Lang, Peter D Zalewski, Sandra J Hodge
Zinc and zinc transporters in macrophages and their roles in efferocytosis in COPD.
PLoS ONE: 2014, 9(10);e110056
[PubMed:25350745] [WorldCat.org] [DOI] (I e)

Eugene Roscioli, Rhys Hamon, Susan Lester, Chiara Murgia, Janet Grant, Peter Zalewski
Zinc-rich inhibitor of apoptosis proteins (IAPs) as regulatory factors in the epithelium of normal and inflamed airways.
Biometals: 2013, 26(2);205-27
[PubMed:23460081] [WorldCat.org] [DOI] (I p)

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